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September 10, 2025Cellular and Molecular ImmunologyOpen Access

Immunoglobulin divalence promotes B-cell antigen receptor cluster scale-dependent functions

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Authors

EYErkan YılmazARA RahimiMMMatthias Münchhalfen

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Overview

Experimental analysis shows monovalent BCRs impair signaling and antigen uptake, highlighting valence in cluster functions.

Key Points

  • Cluster size of B-cell antigen receptors modulates intracellular signaling effectiveness and antigen internalization.
  • Monovalent BCRs demonstrated significantly reduced signaling capabilities and did not enhance sensitivity despite more ITAM incorporation.
  • Advanced imaging techniques revealed that alterations in receptor cluster sizes directly influence cellular response magnitude.
  • Findings contribute to understanding immune receptor function, aiding in synthetic chimeric antigen receptor design.

Cite This Study

Yılmaz et al. (2025) studied this question.

synapsesocial.com/papers/68c241efb210217d647a17c8https://doi.org/10.1038/s41423-025-01327-1
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