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September 10, 2025Annals of Medicine and SurgeryOpen Access

Thrombosis risk in sickle cell disease with HIV co-infection: unraveling the complex interactions and clinical implications – a narrative review

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Authors

EOEmmanuel Ifeanyi Obeagu

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Overview

Narrative review reveals complex interactions between thrombosis, sickle cell disease, and HIV, indicating significant morbidity.

Key Points

  • Thrombosis risk increases significantly in individuals with both sickle cell disease and HIV, complicating treatment approaches.
  • Patients with co-infection experience overlapping symptoms and heightened thrombotic events such as stroke and pulmonary embolism.
  • The narrative review explores mechanisms linking HIV-induced inflammation and sickle cell-related endothelial dysfunction.
  • Effective management of thrombotic complications is crucial due to the significant potential for morbidity and mortality.

Cite This Study

Emmanuel Ifeanyi Obeagu (2025) studied this question.

synapsesocial.com/papers/68c241efb210217d647a0f93https://doi.org/10.1097/ms9.0000000000003533
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hematologic and Immunologic Crossroads: HIV in Sickle Cell Disease Patients2025
  2. 2Antiretroviral Therapy and Sickle Cell Disease: Balancing Efficacy and Toxicity2025
  3. 3A perfect storm: the deadly intersection of sickle cell disease and COVID-192025
  4. 4Treatment disparities in sickle cell disease among patients with asymptomatic HIV2025
  5. 5HIV-1–Infected SCD patients exhibit milder sickle cell disease and suppressed antiviral innate immune responses2025