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August 25, 2025Frontiers in HematologyOpen Access

A perfect storm: the deadly intersection of sickle cell disease and COVID-19

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Authors

AMArturo J Martí-CarvajalAGAlexis Hipólito García

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Overview

This review reveals significant gaps in understanding inflammatory markers in sickle cell disease and COVID-19 interactions, emphasizing their complex implications.

Key Points

  • Significant knowledge gaps exist concerning inflammatory markers in the context of sickle cell disease and COVID-19.
  • The cytokine storm phenomenon underscores the dangerous intersection of chronic inflammation and acute responses in patients.
  • Analysis highlights complications like hyperhaemolysis syndrome and avascular necrosis in sickle cell disease patients amid the pandemic.
  • Understanding these interactions may inform future research directions and improve therapeutic strategies for affected populations.

Cite This Study

Martí-Carvajal et al. (2025) studied this question.

synapsesocial.com/papers/68af79ab7567bf4f94ff1ab8https://doi.org/10.3389/frhem.2025.1651089
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