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October 12, 2025Cellular and Molecular Life SciencesOpen Access

Enhancing anti-tumor immunity by targeting BATF and the STAT1/PD-L1 pathway in cervical carcinoma

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Authors

XPXing PengYZYuanyuan ZhuYHYaqing Han

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Overview

This study demonstrates enhanced anti-tumor immunity through BATF targeting in cervical carcinoma, indicating a vital role for the STAT1/PD-L1 pathway.

Key Points

  • BATF targeting significantly improves anti-tumor immunity, enhancing CD8⁺ and CD4⁺ T-cell infiltration.
  • In vivo, BATF knockdown led to reduced tumor growth and metastasis in cervical carcinoma models.
  • The mechanisms involve BATF's regulation of PD-L1 through the STAT1 pathway, promoting immune evasion.
  • Combination therapy boosts efficacy, suggesting a promising avenue for therapeutic intervention against cervical cancer.

Cite This Study

Peng et al. (2025) studied this question.

synapsesocial.com/papers/68ec1be02b8fa9b2b78ad294https://doi.org/10.1007/s00018-025-05792-9
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