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October 1, 2025CancersOpen Access

Quercetin Increases Expression of Membrane-TRAIL in Glioblastoma Cells Resulting in Apoptosis

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Authors

ETErin M. ThorpeGMGaëlle Muller-GrevenJHJamila Hirbawi

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Overview

Observational analysis shows increased apoptosis in glioblastoma, highlighting quercetin's potential as a treatment.

Key Points

  • Quercetin remarkably induced apoptosis in glioblastoma cell lines, especially M059K, providing a possible therapeutic avenue.
  • The study reports that quercetin increased membrane-TRAIL expression in GBM, enhancing TRAIL-mediated apoptosis in cancer cells.
  • Western blotting and flow cytometry were used to evaluate the effects of quercetin on apoptosis pathways in glioblastoma cells.
  • These findings suggest quercetin's promise as a natural therapeutic agent against glioblastoma without harming normal cells.

Cite This Study

Thorpe et al. (2025) studied this question.

synapsesocial.com/papers/68dd91d5fe798ba2fc4990b5https://doi.org/10.3390/cancers17193197
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