Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Molecular MetabolismOpen Access

A DEL-1/αvβ3 integrin axis promotes brown adipocyte progenitor proliferation and cold-induced brown adipose tissue adaptation

View Full Paper
Ask AI
Bookmark
Share

Authors

KCKyoung‐Jin ChungACAntonios ChatzigeorgiouJLJong‐Hyung Lim

Discussion

Loading...

Member takes

Overview

Observational analysis highlights DEL-1's role in regulating proliferation of brown adipose tissue progenitors, suggesting new therapeutic avenues for enhancing metabolism.

Key Points

  • Increased proliferation of brown adipocyte progenitors enhances cold-induced thermogenesis in brown adipose tissue.
  • Mice lacking DEL-1 showed decreased cold tolerance and reduced adaptation in brown adipose tissue.
  • Manipulations in DEL-1 levels impacted warm thermogenic responses, indicating its critical role in energy metabolism.
  • Crosstalk between DEL-1 and αvβ3 integrin is crucial for cold-induced adaptation of brown adipose tissue.

Cite This Study

Chung et al. (2025) studied this question.

synapsesocial.com/papers/68c24126b210217d6479e4cchttps://doi.org/10.1016/j.molmet.2025.102229
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The TBLR1/TBL1 Co-Factor Complex Acts as a Transcriptional Checkpoint in the Brown Adipose Tissue Response to Prolonged Cold Exposure.2025 · 1 citations
  2. 2Single-nucleus mRNA-sequencing reveals dynamics of lipogenic and thermogenic adipocyte populations in murine brown adipose tissue in response to cold exposure.2025 · 11 citations
  3. 3Alternative Receptor Signaling for the Selective and Multifaceted Regulation of Human Brown Adipocytes2026
  4. 4Endothelial SR-B1 is dispensable for thermogenesis but promotes selective cholesterol uptake in brown adipose tissue2025
  5. 5UCP1 Mitigates Hepatic Steatosis and Fibrosis Independent of Cold Exposure2025