September 10, 2025

The Pharmacogenetics of Opioid Metabolism: A Clinical Perspective

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Discussion

This review uncovers genetic variability in opioid metabolism, emphasizing CYP enzymes and ABCB1 transporters in animals and humans.

Genetic variability significantly affects opioid metabolism, which influences drug response and efficacy.
Findings highlight the importance of CYP2D variations in codeine metabolism across different rat strains.
Animal studies of pharmacogenetics offer valuable insights for human opioid therapy development and risk assessment.
Insufficient genomic databases and limited genetic diversity in animal models create important gaps in research.

Kumar et al. (2025) studied this question.

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