A GWAS Meta-meta-analysis and In-depth Silico Pharmacogenomic Investigations in Identification of APOE and Other Genes Associated with Pain, Anti-inflammatory, and Immunomodulating Agents in Opioid Use Disorder (OUD) Derived from 14.91 M Subjects

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Discussion

Meta-analysis identifies key genes like APOE and immune biomarkers in opioid use disorder, implying personalized treatment strategies.

Main finding reveals a strong association between APOE and opioid use disorder, suggesting new recovery strategies.
Candidate genes related to pain and inflammatory responses were identified and refined through in silico methods.
Five GWAS traits including pain and inflammatory biomarkers were analyzed to understand their genetic interactions.
Significant pharmacogenomic insights link multiple genes to opioid dependence, emphasizing personalized medication approaches.

Sharafshah et al. (2025) studied this question.

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