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September 10, 2025BMC GastroenterologyOpen Access

Relationship between gut microbiota dysbiosis and bile acid in patients with hepatitis B-induced cirrhosis

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Authors

YLYannan LiDZDan ZhangTTTian Tian

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Overview

Observational analysis shows changes in gut microbiota diversity in hepatitis B-related cirrhosis cases, suggesting bile acid's role.

Key Points

  • Patients with hepatitis B-related cirrhosis exhibited significant gut microbiota dysbiosis.
  • The study observed decreased alpha diversity of gut microbiota in hepatitis B patients compared to healthy adults.
  • Fecal samples analyzed using 16 S rRNA sequencing provided insights into microbiota changes associated with bile acid levels.
  • These findings indicate potential targets for biomarkers and microbiota-focused therapies in hepatitis B management.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479d2c1https://doi.org/10.1186/s12876-025-04159-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A metagenome-wide association study of gut microbiota in hepatitis B virus-related cirrhosis in northwest China2025
  2. 2Fecal Microbiota and Bile Acid Profiles in Early-Stage Hepatocellular Carcinoma: A Matched Case-Control Study2025 · 1 citations
  3. 3Hepatitis B Virus-Related Liver Disease and Gut Microbiota: An Updated Review2025
  4. 4Role of the gut microbiota–bile acid axis in liver fibrosis based on microbiomics and targeted metabolomics2026
  5. 5Fecal microbiome profiles in infants with biliary atresia versus nonbiliary atresia cholestasis: a pilot study2025