Matched case-control study reveals limited differences in microbiota and bile acid profiles between HCC and cirrhosis patients, suggesting further research needed.
Key Points
Increased concentration of secondary bile acids was associated with higher odds of hepatocellular carcinoma.
In the study of 98 patients, the prevalence of Hepatitis C was significantly higher in those with HCC.
The case-control study found limited differences in microbiota composition between patients with cirrhosis and early-stage HCC.
Differential abundance of taxa like Klebsiella pneumoniae was noted in cases, indicating potential biomarkers.