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September 10, 2025International Journal of Gynecological Pathology

Abnormal Nuclear Membranous Staining Pattern by MLH1 Immunohistochemistry in Endometrial Cancer: A Diagnostic Pitfall and Clone-dependent Artifact

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Authors

LWLisha WangDJDavid JouRPRuchi Patel

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Overview

Observational analysis identified abnormal MLH1 staining in endometrial cancer, suggesting diagnostic pitfalls associated with MMR proteins.

Key Points

  • Nuclear membranous expression of MLH1 was noted in 6 out of 41 cases with PMS2 loss.
  • MLH1 promoter hypermethylation was detected in 6 out of 7 tested cases, indicating a connection to abnormal staining.
  • Observational analysis across 52 endometrial cancer cases revealed a significant ambiguity in IHC interpretations.
  • Recognizing abnormal MLH1 patterns is crucial, as failing to do so may result in misinterpreted PMS2 deficiencies.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479cd4ehttps://doi.org/10.1097/pgp.0000000000001125
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Microsatellite Instability in Endometrial Hyperplasia and Risk of Carcinoma Development2025
  2. 2Evaluation of microsatellite instability patterns in mismatch repair deficiency: a retrospective analysis of 285 endometrial cancers2025
  3. 3Prognostic and Clinicopathological Implications of Mismatch-Repair Deficiency and MLH1 Promoter Methylation Status in Endometrial Carcinoma2025
  4. 4Mismatch Repair Gene Deficiency in Ovarian Cancer: A Clinicopathological Analysis of MLH1, PMS2, MSH2, and MSH6 Mutations Across Histological Subtypes2025
  5. 5Immunohistochemical Expression of MLH1, PMS2 and P53 in Colorectal Carcinoma with Clinicopathologic Correlation2025