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August 19, 2025Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 )Open Access

Immunohistochemical Expression of MLH1, PMS2 and P53 in Colorectal Carcinoma with Clinicopathologic Correlation

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Authors

SASaif Raghad Saleem AlhamadaniZAZainab Khalid Shehab Almukhtar

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Overview

Cross-sectional study finds MLH1 loss linked to right colon tumors, highlighting p53's role in prognostic evaluations.

Key Points

  • MLH1 loss is associated with right colon tumors and T3 extension, indicating potential prognostic implications.
  • PMS2 absence is linked with moderate tumor differentiation and clear resection margins, revealing critical clinical correlations.
  • Immunohistochemical analysis of MLH1, PMS2, and p53 in 102 colorectal carcinomas indicated significant associations among these proteins.
  • Understanding these correlations may enhance clinical criteria for detecting patients with colorectal carcinoma risks.

Cite This Study

Alhamadani et al. (2025) studied this question.

synapsesocial.com/papers/68af33ddcf1dd9ea359e8a05https://doi.org/10.54133/ajms.v9i1.2181
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