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September 20, 2025Frontiers in ChemistryOpen Access

Integrated analysis of stem cell-related genes shared between type 2 diabetes mellitus and sepsis

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Authors

YWYubo WangXJXinhai JiangXSXiaohan Song

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Overview

Integrated analysis uncovers common stem cell-related genes in type 2 diabetes and sepsis, indicating potential therapeutic avenues.

Key Points

  • Common stem cell-related biomarkers CAPG and DDAH2 were significantly expressed in both type 2 diabetes and sepsis.
  • High expression of CAPG and DDAH2 is associated with immune response pathways and ribosomal function.
  • Functional enrichment analysis revealed notable immune differences between type 2 diabetes, sepsis, and control groups.
  • The study validated findings at both transcriptional and protein levels using an in vitro T2DM-sepsis model.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68d439f4713b0b5dfea79a4fhttps://doi.org/10.3389/fchem.2025.1666651
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