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September 10, 2025International Journal of Pharmaceutical Science Invention

Formulation and In Vitro Characterization of Clonidine HCl Transdermal Drug Delivery System

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Authors

ABAruna Baswaraju Aruna BaswarajuMSM. SudhanBBB.Sowmya Mishra B.Nagaraju

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Overview

Matrix-type transdermal patches of clonidine hydrochloride improved bioavailability in hypertension treatment, suggesting effectiveness.

Key Points

  • Formulation F4 achieved maximum cumulative drug release of 99.34% over 12 hours, indicating high efficiency.
  • The study used a Franz diffusion cell to evaluate drug release kinetics, confirming it followed Zero-order kinetics.
  • The transdermal patches showed excellent drug-excipient compatibility with no significant interactions detected.
  • The physical characteristics of all formulations were satisfactory, aligning with the intended design for improved patient compliance.

Cite This Study

Baswaraju et al. (2025) studied this question.

synapsesocial.com/papers/68c2409bb210217d6479b911https://doi.org/10.35629/6718-14040616
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