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August 17, 2025Research Journal of Pharmacy and Technology

Formulation and In vitro Evaluation of Matrix Patch of Doxazosin Mesylate for Transdermal Delivery

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Authors

NMNimmathota MadhaviCSCh. SaikiranBMB. Mounika

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Overview

In vitro evaluation shows improved drug release in patches formulated with doxazosin mesylate, indicating enhanced delivery efficacy.

Key Points

  • Maximum drug release achieved in 12 hours, indicating effective transdermal delivery of doxazosin mesylate.
  • Formulation utilized the solvent casting method with varying ratios of HPMCK100 and PVP K30 polymers for optimal results.
  • Evaluation included drug release studies and kinetics, revealing first-order drug release and diffusion processes.
  • Study highlights improvement in bioavailability over traditional oral delivery methods, suggesting a potential advance in treatment for benign prostatic hyperplasia.

Cite This Study

Madhavi et al. (2025) studied this question.

synapsesocial.com/papers/68c23652b210217d64774245https://doi.org/10.52711/0974-360x.2025.00478
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