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September 10, 2025International Journal of Biological SciencesOpen Access

Lactate metabolic reprogramming and histone lactylation modification in sepsis

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Authors

JZJi ZhangDWDan WuZFZeng Fu

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Overview

This review highlights lactate's role as a biomarker in sepsis and explores how lactylation modifies immune responses.

Key Points

  • Lactylation significantly alters protein function in sepsis, impacting immune responses and energy metabolism.
  • The review discusses the roles of lactate levels and lactylation patterns in regulating inflammation during sepsis.
  • Current research indicates potential targeted therapies focused on lactylation pathways could improve sepsis outcomes.
  • Limitations in lactylation research methodologies underscore the need for further investigation in critical illness contexts.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c2404eb210217d6479a01dhttps://doi.org/10.7150/ijbs.116088
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of novel protein acylation modifications in sepsis2025
  2. 2The Role of Lactate in Immune Regulation: A Metabolic Rheostat via Transporters, Receptors, and Epigenetic Modifiers2025
  3. 3Targeting Lactylation: From Metabolic Reprogramming to Precision Therapeutics in Liver Diseases2025
  4. 4The Epigenetics of Sepsis: How Gene Modulation Shapes Outcomes2025
  5. 5Lactate: elucidating its indispensable role in human health2026