Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 26, 2025CellsOpen Access

The Role of Lactate in Immune Regulation: A Metabolic Rheostat via Transporters, Receptors, and Epigenetic Modifiers

View Full Paper
Ask AI
Bookmark
Share

Authors

ECEun Jung ChoiYJYoon Young JangECEun Joo Choi

Discussion

Loading...

Member takes

Overview

Review shows lactate's dual role in inflammation and immunity in various diseases, indicating its potential in immunotherapy.

Key Points

  • MAIN FINDING: Lactate acts as an immunometabolic regulator, influencing immune responses in health and disease.
  • KEY EVIDENCE: The review covers mechanisms of lactate accumulation in conditions like cancer, sepsis, and diabetes.
  • APPROACH: Integrated mechanisms of lactate modulation via transporters, receptors, and epigenetic modifications were examined.
  • SIGNIFICANCE: Understanding lactate's role can guide the design of therapies that modulate immune responses effectively.

Cite This Study

Choi et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce581https://doi.org/10.3390/cells14141096
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lactate: elucidating its indispensable role in human health2026
  2. 2How lactate and lactylation shape the immunity system in atherosclerosis (Review)2025
  3. 3The Role of Lactate Metabolism in Tumors2025 · 6 citations
  4. 4Dual role of lactate in human health and disease2025
  5. 5Research Progress on Lactate-Mediated Tumor Metabolic Microenvironment-Driven Immunotherapy and Metabolic Reprogramming Strategies2025