September 10, 2025Frontiers in PediatricsOpen Access

Analysis of risk factors for Epstein–Barr virus reactivation and progression to post-transplant lymphoproliferative disorder in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation

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EBV reactivation is common in pediatric patients after HSCT, affecting 256 out of 309 patients within one year.
The independent risk factor for EBV reactivation identified was ATG, emphasizing its role in post-transplant complications.
Grade III-IV acute graft-vs.-host disease was linked to progression to PTLD, highlighting significant postoperative risks.
Regular monitoring of EBV-DNA load is crucial for preventing and managing PTLD after HSCT.

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Implication

Retrospective analysis identifies key risk factors for EBV reactivation and PTLD in pediatric patients, suggesting the need for regular EBV monitoring.

Cite This Study

Jia et al. (2025) studied this question.

synapsesocial.com/papers/68c23fc3b210217d647979ea https://doi.org/10.3389/fped.2025.1627990

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Implication

Retrospective analysis identifies key risk factors for EBV reactivation and PTLD in pediatric patients, suggesting the need for regular EBV monitoring.

Analysis of risk factors for Epstein–Barr virus reactivation and progression to post-transplant lymphoproliferative disorder in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation

Key Points

Discussion

Implication

Cite This Study

Analysis of risk factors for Epstein–Barr virus reactivation and progression to post-transplant lymphoproliferative disorder in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation

Key Points

Discussion

Implication

Cite This Study

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