September 12, 2025CureusOpen Access

Early-Onset Epstein-Barr Virus (EBV)-Positive Post-transplant Lymphoproliferative Disorder Presenting With Catastrophic Gastrointestinal Hemorrhage and Ischemic Bowel Following Kidney Transplantation

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Case report highlights aggressive ptld outcomes linked to ebv infection in kidney transplant, suggesting urgent early intervention.

The patient developed severe gastrointestinal hemorrhage and ischemic bowel due to EBV-positive PTLD within six months post-transplant.
Despite intervention with rituximab therapy and immunosuppression adjustment, the patient's condition worsened and led to death.
Early recognition and multidisciplinary management are critical for such aggressive cases, yet may still be inadequate in advanced disease.
EBV monitoring and tailored immunosuppression are crucial for improving outcomes in transplant recipients at increased risk.

Davuluri et al. (2025) studied this question.

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