December 8, 2025Blood

Ectopic EBV infection in T cells following allogeneic hematopoietic stem cell transplantation: Clinical outcomes and immunological characterization

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T-cell EBV infection correlates with higher PTLD incidence and T-cell functional exhaustion in allo-HSCT patients.
Of the cohort, 62.6% developed PTLD, with T-cell infected patients showing a 69.5% PTLD rate compared to 45.2% for others.
Observational analysis used flow cytometry and CyTOF to assess immune reconstitution, with key findings on T-cell dynamics noted.
Early post-transplant EBV DNAemia serves as a predictive marker for T-cell infection, calling for focused immunotherapeutic strategies.

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Analysis reveals T-cell EBV infection increases PTLD risk in allo-HSCT, suggesting need for targeted monitoring and therapies.

Lan‐Ping Xu (2025) studied this question.

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