Nrf2 Pathway Involvement in the Central Nervous System

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Nrf2 activation protects neurons from oxidative injury, and supports overall brain homeostasis.
Compounds like dimethyl fumarate and sulforaphane show promising neuroprotective effects through nrf2 activation.
Dysregulation of nrf2 is linked to various neurodegenerative disorders and acute neurological injuries.
Understanding nrf2's role helps develop therapeutic approaches targeting oxidative stress in the CNS.

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This review highlights key relationships between nrf2 signaling, oxidative stress, and neurodegenerative diseases.

Ali et al. (2025) studied this question.

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