August 25, 2025AntioxidantsOpen Access

Non-Electrophilic Activation of NRF2 in Neurological Disorders: Therapeutic Promise of Non-Pharmacological Strategies

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Non-pharmacological interventions activate nrf2 through non-canonical pathways, providing neuroprotective benefits without toxicity.
The evidence highlights that traditional electrophilic activators generate oxidative stress, undermining their therapeutic effect.
Emerging non-electrophilic activators show potential but face challenges in bioavailability and potency, necessitating innovative strategies.
Comprehensive analyses of multi-mechanistic approaches show how non-pharmacological methods can optimally utilize nrf2 pathways.

Discussion

Review reveals non-pharmacological strategies enhance nrf2 activation in neurological disorders, suggesting therapeutic promise.

Li et al. (2025) studied this question.

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