September 10, 2025ESC Heart FailureOpen Access

The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches

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Nrf2 modulation may reduce oxidative stress and inflammation, improving heart failure symptoms.
Evidence shows Nrf2 activity is impaired in heart failure, contributing to myocardial dysfunction and progression.
Therapeutic strategies, including lifestyle changes and cardiovascular agents, show potential in restoring Nrf2 activity.
The review highlights the complexity of Nrf2's role in heart failure, emphasizing the need for further exploration and validation.

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Review reveals Nrf2 impacts oxidative stress and inflammation in heart failure, suggesting therapeutic approaches.

Fiori et al. (2025) studied this question.

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