September 10, 2025International Journal of Pharmacy and Pharmaceutical SciencesOpen Access

In Vivo Evaluation of Ph-Responsive Eudragit® S-100 Coated Chitosan Nanoparticles for Targeted Curcumin Delivery in Ulcerative Colitis

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Authors

NSNEELESH KUMAR SAHU NLNarendra Kumar LariyaRKDF University

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Implication

In vivo evaluation shows curcumin-loaded nanoparticles improve anti-inflammatory effects in ulcerative colitis models, indicating enhanced therapeutic potential.

Key Points

Curcumin-loaded nanoparticles significantly improved clinical outcomes in an ulcerative colitis model, stabilizing weight and reducing symptoms.
Weight loss in colitis controls was pronounced, contrasting with stabilization in nanoparticle-treated groups, highlighting their efficacy.
Assessment included multiple measures such as colon/body weight ratio and MPO activity, indicating robust improvement over controls.
Histological analysis revealed preserved mucosal integrity in nanoparticle groups compared to severe ulceration in controls.

Cite This Study

SAHU et al. (2025) studied this question.

synapsesocial.com/papers/68c23fc3b210217d647974dd https://doi.org/10.22159/ijpps.2025v17i8.54905

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Implication

In vivo evaluation shows curcumin-loaded nanoparticles improve anti-inflammatory effects in ulcerative colitis models, indicating enhanced therapeutic potential.

In Vivo Evaluation of Ph-Responsive Eudragit® S-100 Coated Chitosan Nanoparticles for Targeted Curcumin Delivery in Ulcerative Colitis

Discussion

Member takes

Implication

Key Points

Cite This Study

In Vivo Evaluation of Ph-Responsive Eudragit® S-100 Coated Chitosan Nanoparticles for Targeted Curcumin Delivery in Ulcerative Colitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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