September 10, 2025Journal of Agricultural and Food Chemistry

Eliminating ROS and Alleviating Inflammation to Restore the Integrity of Intestinal Epithelium in DSS-Induced Ulcerative Colitis by a pH-Responsive Delivery System of Curcumin

View Full Paper

Ask AI

Bookmark

Authors

RLRuili LiBeijing Forestry University YXYe XiaoHarbin Medical University RWRui WuInstitute for Literature

Discussion

Member takes

Implication

Observational analysis reveals curcumin's effectiveness in alleviating inflammation in ulcerative colitis, indicating potential for improved treatment options.

Key Points

The CUR delivery system significantly reduces pro-inflammatory cytokine expression, improving colon health.
In DSS-treated mice, CURDNPs@CUR achieved notable restoration of intestinal epithelial integrity and permeability.
The polymer nanoparticles enhance curcumin's bioavailability and controlled-release performance for targeted therapy.
Findings support the use of a pH-responsive curcumin delivery system as a strategy for managing ulcerative colitis.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c23fc3b210217d64797b18 https://doi.org/10.1021/acs.jafc.4c13100

View Full Paper

Ask AI

Bookmark

Implication

Observational analysis reveals curcumin's effectiveness in alleviating inflammation in ulcerative colitis, indicating potential for improved treatment options.