Abstract A087: Spatial-resolved single-cell analysis of the tumor microenvironment in Alaska Native colorectal cancer patients reveals novel biomarkers for prognosis

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Spatial proteomics reveals novel biomarkers for colorectal cancer prognosis in Alaska Native patients, indicating critical cellular interactions.

Higher proportions of stromal cells are linked to increased risks of colorectal cancer-specific death, and colocalization patterns reveal critical immune interactions.
Patients with a doubling of M2 macrophage proportions at the tumor center have a 2.90 odds ratio for CRC mortality, underlining the importance of immune cells in prognosis.
This study utilized spatial proteomics profiling on tissue microarrays from 97 Alaska Native colorectal cancer patients to assess tumor microenvironment characteristics.
The findings suggest specific cell interactions in the tumor microenvironment may serve as prognostic biomarkers for colorectal cancer outcomes.

Yin et al. (2025) studied this question.

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Spatial proteomics reveals novel biomarkers for colorectal cancer prognosis in Alaska Native patients, indicating critical cellular interactions.