In Silico Study of Brazilin from Secang Wood (Caesalpinia Sappan L) as a Candidate for Splenomegaly Therapy

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In silico study reveals brazilin's potential as a JAK2 inhibitor, indicating therapeutic strategies for splenomegaly in thalassemia.

Brazilin exhibits binding energy comparable to ruxolitinib, potentially reducing splenomegaly.
The in silico analysis predicts brazilin's pharmacokinetic properties and JAK2 inhibitory activity.
Molecular docking studies demonstrate effective binding interactions between brazilin and JAK2.
These findings suggest brazilin could be an alternative treatment for splenomegaly in thalassemia patients.

Youngest et al. (2025) studied this question.

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