Anticancer Activity of Combined Extracts of Sappan Wood (Caesalpinia sappan L.) and Coffee Stem Parasite (Loranthus ferrugineus Roxb) Against MCF7 Breast Cancer Cells Through In Silico and In Vitro Approaches

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In silico and in vitro analyses reveal anticancer potential of Caesalpinia sappan and Loranthus ferrugineus, indicating complex interactions.

Combined extracts of Caesalpinia sappan and Loranthus ferrugineus exhibited antagonistic effects against MCF-7 breast cancer cells.
In vitro, Caesalpinia sappan showed moderate cytotoxicity with an IC50 of 56.21 µg/mL, while Loranthus ferrugineus had 112.9 µg/mL.
In silico docking suggested promising binding affinities for brazilin and quercetin, the key phytoconstituents, at -8.2 kcal/mol and -8.9 kcal/mol, respectively.
Extract combinations demonstrated inactivity, highlighting complex interactions of secondary metabolites affecting anticancer efficacy.

Juwitaningsih et al. (2025) studied this question.

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In silico and in vitro analyses reveal anticancer potential of Caesalpinia sappan and Loranthus ferrugineus, indicating complex interactions.