Comprehensive investigation into the preventive and therapeutic efficacy and underlying mechanisms of phycocyanin in diabetic retinopathy in rats

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Animal study demonstrates phycocyanin improves symptoms of diabetic retinopathy in rats, suggesting underlying mechanisms involving NF-κB and VEGF.

Phycocyanin significantly improved symptoms in diabetic rats, including reduced weight loss and blood glucose levels.
After 16 weeks, treated rats showed enhanced retinal thickness and reduced NF-κB and VEGF overexpression.
The analysis revealed that phycocyanin lowers inflammatory markers IL-6 and TNF-α, pointing to its protective effects.
These findings indicate phycocyanin's potential as a therapeutic agent for diabetic retinopathy in clinical settings.

Sun et al. (2025) studied this question.

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Animal study demonstrates phycocyanin improves symptoms of diabetic retinopathy in rats, suggesting underlying mechanisms involving NF-κB and VEGF.