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July 30, 2025AntioxidantsOpen Access

Modulation of Oxidative Stress in Diabetic Retinopathy: Therapeutic Role of Natural Polyphenols

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Authors

VGVerónica Gómez-JiménezRMRaquel Burggraaf-Sánchez de las MatasÁOÁngel Ortega

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Overview

Preclinical evidence suggests polyphenols improve oxidative stress and neurodegeneration in diabetic retinopathy, highlighting a potential therapeutic approach.

Key Points

  • Diabetic retinopathy is a significant cause of blindness in adults, driven by oxidative stress and vascular dysfunction.
  • Emerging therapies focus on targeting oxidative stress and neurodegeneration, with polyphenols showing potential therapeutic benefits.
  • Polyphenols have antioxidant and anti-inflammatory properties but face challenges due to low bioavailability.
  • Utilizing nanotechnology can enhance the delivery and efficacy of polyphenols for early intervention in diabetic patients.

Cite This Study

Gómez-Jiménez et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cee9ehttps://doi.org/10.3390/antiox14070875
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Resveratrol as a Novel Therapeutic Approach for Diabetic Retinopathy: Molecular Mechanisms, Clinical Potential, and Future Challenges2025
  2. 2Nitro-oxidative Mechanism and Therapeutic Potential in Diabetic Retinopathy2025
  3. 3Diabetic Retinopathy in Focus: Update on Treatment Advances, Pharmaceutical Approaches, and New Technologies2025
  4. 4Breakthroughs in diabetic retinopathy diagnosis and treatment using preclinical research models: current progress and future directions2025
  5. 5Targeting microRNAs in diabetic retinopathy: from pathogenic mechanisms to therapeutic potentials2025 · 4 citations