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September 10, 2025Journal Syifa Sciences and Clinical ResearchOpen Access

Formulation and Evaluation of a Chitooligosaccharide Peel-Off Gel Mask for Anti-Acne Activity Against Propionibacterium acnes

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Authors

EAElsa Fitria AprianiMMMiksusanti MiksusantiVAVitri Agustiarini

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Overview

The study evaluates a chitooligosaccharide-based mask's antibacterial activity against Propionibacterium acnes, suggesting its role in acne treatment.

Key Points

  • F3, with 0.75% chitooligosaccharide, shows the best physical properties and antibacterial effect against Propionibacterium acnes.
  • The optimal formulation exhibited a significant inhibition zone of 21.67 ± 1.65 mm against the bacteria, indicating strong antibacterial activity.
  • Minimum inhibitory conc. for F3 was 1250 ppm, MBC was 2500 ppm, highlighting its potential effectiveness as an anti-acne treatment.
  • Physical stability was shown with clear and homogeneous gel properties, affirming the formulation's suitability for topical use.

Cite This Study

Apriani et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d647906c7https://doi.org/10.37311/jsscr.v7i2.33440
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