In vitro and in vivo studies of natural anti- acne treatments from pomegranate pericarp extract and essential oils of bitter orange, sweet marjoram, and tea tree
In vitro and in vivo evaluations demonstrate antibacterial potential of pomegranate extract and essential oils, suggesting safe alternatives for acne treatment.
Key Points
Pomegranate pericarp extract and essential oils reduced bacterial load and inflammation in acne models, showing promising results.
Bitter orange oil displayed a minimum inhibitory concentration of 0.21 mg/mL against Cutibacterium acnes, outperforming conventional antibiotics.
Formulations with pomegranate extract and essential oils exhibited significant anti-inflammatory efficacy in in vivo tests on acne-induced mice.
The regular gel formulation shows potential as a cost-effective alternative without compromising on efficacy in acne treatment.