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September 10, 2025Open Access

Long‐term risk prediction of diabetes mellitus using the 100‐g oral glucose tolerance test during pregnancy: Insights into test patterns, single abnormal values, and abnormal fasting glucose

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Authors

YSYael Winter ShafranTSTal SchillerAKAlena Kirzhner

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Overview

Retrospective cohort study shows abnormal OGTT patterns predict future diabetes in pregnant individuals, highlighting significant risks related to abnormal glucose measurements.

Key Points

  • Over 21% with ≥2 abnormal OGTT results developed diabetes, indicating strong predictive value.
  • Participants with one abnormal glucose measurement, particularly fasting glucose, had a high risk of subsequent diabetes.
  • Hazard ratios indicate escalating risk of developing diabetes with increasing abnormal glucose results.
  • Older, more obese individuals with pathological OGTT patterns had higher diabetes development rates.

Cite This Study

Shafran et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d647902cbhttps://doi.org/10.1002/pmf2.70058
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The utility of early gestational OGTT and biomarkers for the development of gestational diabetes mellitus: an international prospective multicentre cohort study2025
  2. 2Metabolic recovery at 12 months postpartum among individuals with glucose intolerance in pregnancy2025
  3. 3Pancreatic beta-cell secretory products in the diagnosis and risk stratification of gestational diabetes mellitus: a prospective longitudinal cohort study2025
  4. 4Solely Elevated Fasting Glucose Level In Glucose Tolerance Test: A Dilemma For Diagnosis of GDM2025
  5. 5Analysis of glucose metabolism outcomes 4–7 years postpartum in women with gestational diabetes mellitus using continuous glucose monitoring maternal risk factors: a Chinese cohort study2025