Circadian Light Manipulation and Melatonin Supplementation Enhance Morphine Antinociception in a Neuropathic Pain Rat Model

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Circadian-aligned lighting preserved melatonin levels and mitigated morphine tolerance in neuropathic pain models.
Melatonin co-infusion significantly enhanced morphine analgesia and reduced markers of inflammation during opioid tolerance development.
Rats exposed to constant light exhibited exacerbated pain behaviors and heightened morphine tolerance compared to those in circadian conditions.
Findings indicate the importance of circadian rhythms and melatonin in optimizing opioid treatments for neuropathic pain.

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This study evaluates light manipulation and melatonin in enhancing morphine analgesia in rats, suggesting improved pain management strategies.

Huang et al. (2025) studied this question.

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This study evaluates light manipulation and melatonin in enhancing morphine analgesia in rats, suggesting improved pain management strategies.