August 26, 2025Molecular PainOpen Access

EXPRESS: Inhibition of mTOR/S6K1/Gli1 signaling alleviates morphine-induced thermal hyperalgesia and tolerance

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Blocking mTOR signaling alleviated thermal hyperalgesia induced by repeated morphine treatment, and reduced BDNF levels.
The significant reduction in heat sensitivity was linked to the suppression of the mTOR/S6K1/Gli1 pathway, demonstrating its role in morphine tolerance.
Adult CD-1 mice were used in a series of behavioral and neurochemical assessments after morphine treatment, highlighting the non-canonical role of sonic hedgehog signaling.
These findings suggest targeting the mTOR pathway may be a valid approach to develop new treatments for opioid-induced hyperalgesia and tolerance.

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Implication

Experimental results show that blocking mTOR signaling reduces morphine-induced thermal hyperalgesia and BDNF levels, suggesting new therapeutic avenues.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68af7e047567bf4f94ff5938 https://doi.org/10.1177/17448069251376198

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Implication

Experimental results show that blocking mTOR signaling reduces morphine-induced thermal hyperalgesia and BDNF levels, suggesting new therapeutic avenues.

EXPRESS: Inhibition of mTOR/S6K1/Gli1 signaling alleviates morphine-induced thermal hyperalgesia and tolerance

Key Points

Discussion

Implication

Cite This Study

EXPRESS: Inhibition of mTOR/S6K1/Gli1 signaling alleviates morphine-induced thermal hyperalgesia and tolerance

Key Points

Discussion

Implication

Cite This Study

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