August 18, 2025Molecular PainOpen Access

EXPRESS: CB2 receptor agonist AM1241 regulating the polarization of microglia reduces morphine tolerance through IL-4/STAT6 pathway

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CB2 receptor agonist AM1241 increased IL-4 levels and reduced morphine tolerance in mice, indicating a significant interaction with microglial polarization.
After AM1241 treatment, PWL improved, and markers for inflammatory response shifted, demonstrating its potential in managing morphine tolerance.
Analysis of microglial responses revealed that AM1241 regulated M2 polarization via the IL-4/STAT6 pathway, emphasizing its therapeutic implications.
This research suggests targeting microglial polarity could open new avenues for treating morphine tolerance, though further studies are warranted.

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Observational analysis shows microglial polarization affects morphine tolerance in mice, indicating IL-4 may play a key regulatory role.

Cui et al. (2025) studied this question.

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