September 10, 2025Journal of the National Comprehensive Cancer Network

Olanzapine for Anorexia in Patients With Incurable Cancer and Cachexia (OlAnCa): A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

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Authors

NON. Othman HAHesham H. Abdel-Aal WEWessam A. El-Sherief

Discussion

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Overview

Randomized clinical trial shows olanzapine improves anorexia scores in patients with incurable cancer, suggesting potential benefits for cachexia management.

Key Points

Olanzapine treatment led to a median reduction in anorexia scores after one week, unlike placebo, indicating a promising intervention.
After 4 weeks, 14% of patients on olanzapine gained significant weight compared to none on placebo, supporting its efficacy.
The double-blind, placebo-controlled, randomized clinical trial included 164 participants with incurable cancer and cachexia.
Findings highlight the necessity for further research into the long-term safety of olanzapine for managing cancer-associated anorexia.

Cite This Study

Othman et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d6479001e https://doi.org/10.6004/jnccn.2025.7033

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September 10, 2025Journal of the National Comprehensive Cancer Network

Olanzapine for Anorexia in Patients With Incurable Cancer and Cachexia (OlAnCa): A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

View Full Paper

Ask AI

Bookmark

Authors

NON. Othman HAHesham H. Abdel-Aal WEWessam A. El-Sherief

Discussion

Member takes

Overview

Randomized clinical trial shows olanzapine improves anorexia scores in patients with incurable cancer, suggesting potential benefits for cachexia management.

Key Points

Olanzapine treatment led to a median reduction in anorexia scores after one week, unlike placebo, indicating a promising intervention.
After 4 weeks, 14% of patients on olanzapine gained significant weight compared to none on placebo, supporting its efficacy.
The double-blind, placebo-controlled, randomized clinical trial included 164 participants with incurable cancer and cachexia.
Findings highlight the necessity for further research into the long-term safety of olanzapine for managing cancer-associated anorexia.

Cite This Study

Othman et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d6479001e https://doi.org/10.6004/jnccn.2025.7033

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