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December 8, 2025BMJ Supportive & Palliative Care

Mirtazapine and olanzapine for cancer-related psychological distress in advanced oral cancer: efficacy and safety prospective study

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Authors

SPSurendra Kumar PingoliyaPRPavan Gaurav R

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Overview

Prospective study shows mirtazapine effectively reduces anxiety and depression in cancer patients, suggesting improvements in quality of life and treatment adherence.

Key Points

  • Both mirtazapine and olanzapine reduced anxiety and depression significantly, enhancing overall well-being.
  • Mirtazapine led to a decrease in anxiety from 14.10 at admission to 10.28 at four weeks, showing superior efficacy.
  • This prospective study involved 144 oral cancer patients allocated into two treatment groups for comparison.
  • The findings support mirtazapine as the preferred choice for managing psychological distress in this population.

Cite This Study

Pingoliya et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4bbhttps://doi.org/10.1136/spcare-2025-005706
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Olanzapine for Anorexia in Patients With Incurable Cancer and Cachexia (OlAnCa): A Double-Blind, Placebo-Controlled, Randomized Clinical Trial2025
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  3. 3Investigating the effects of olanzapine on appetite and weight in patients with cancer in a systematic review2026
  4. 4Therapeutic Effects and Safety of Mirtazapine for Insomnia in Major Depressive Disorder: Findings from a 6-Week Open-Label Pre- and Post-Intervention Study2025
  5. 5Olanzapine Plus Triple Antiemetic Therapy for the Prevention of Platinum-Based Delayed-Phase Chemotherapy-Induced Nausea and Vomiting: A Meta-Analysis2026