September 10, 2025Geriatric CareOpen Access

A network meta-analysis of anorexia treatments in disease and old age: pharmacogenomics, the gut-brain axis and artificial neural nets. Where are we?

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Network meta-analysis reveals effectiveness of treatments for anorexia in elderly patients, highlighting pharmacogenomics and artificial neural nets.

Olanzapine showed the highest effectiveness among anorexia treatments, with a significant pooled effect size of 0.87.
The analysis included 74 studies and 16,390 patients, covering various treatments for elderly and chronically ill individuals.
Network meta-analysis utilized Bayesian and frequentist methods to validate outcomes and predictors of treatment response.
Findings suggest drug repositioning of olanzapine and nutritional supplementation may enhance anorexia treatments.

Korsavva et al. (2025) studied this question.

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Network meta-analysis reveals effectiveness of treatments for anorexia in elderly patients, highlighting pharmacogenomics and artificial neural nets.