September 10, 2025Communications BiologyOpen Access

A multi-tissue human knee single-cell atlas identifies that osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages

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Osteoarthritis significantly reduces regenerative tissue stem cells and increases inflammatory macrophages in knee tissues.
Healthy knee tissues harbor abundant tissue stem cells and immune cells, which are altered in osteoarthritis.
This study used single-cell RNA sequencing to identify specific harmful chondrocytes and their role in OA progression.
Identifying OA-specific cells and molecular interactions may help in developing targeted therapies for osteoarthritis.

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Single-cell analysis demonstrates changes in tissue stem cells and macrophages in osteoarthritis, indicating molecular mechanisms of pain.

Raut et al. (2025) studied this question.

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Single-cell analysis demonstrates changes in tissue stem cells and macrophages in osteoarthritis, indicating molecular mechanisms of pain.