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September 12, 2025Advanced ScienceOpen Access

A Compartmentalized Joint‐on‐chip (JoC) Model to Unravel the Contribution of Cartilage and Synovium to Osteoarthritis Pathogenesis

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Authors

CPCecilia PalmaSSShima SalehiMPMichela Anna Polidoro

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Overview

Compartmentalized JoC model reveals cartilage-synovium interactions in osteoarthritis, suggesting inflammatory pathways.

Key Points

  • The joint-on-chip model shows that inflamed synovium induces early cartilage degradation.
  • Mechanical damage to cartilage activates macrophages and promotes inflammation in the synovium.
  • This model enables controlled study of complex tissue interactions in osteoarthritis pathogenesis.
  • Understanding these interactions can guide the development of effective treatments for osteoarthritis.

Cite This Study

Palma et al. (2025) studied this question.

synapsesocial.com/papers/68d41da8713b0b5dfea66e1ehttps://doi.org/10.1002/advs.202500374
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