September 10, 2025Frontiers in MedicineOpen Access

Epithelial–mesenchymal transition in pulmonary fibrosis: molecular mechanisms and emerging therapeutic strategies

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This review explores epithelial-mesenchymal transition's role in pulmonary fibrosis, highlighting emerging therapeutic strategies.

Epithelial-mesenchymal transition is a significant mechanism in pulmonary fibrosis, contributing to lung scarring.
Key evidence suggests involvement of growth-factor signals and immune crosstalk in fibrotic remodeling.
Recent studies utilize lung organoids and single-cell profiling to identify targeted therapies for pulmonary fibrosis.
Emerging therapies include antifibrotics and experimental medicines that may reverse the effects of epithelial stress.

Li et al. (2025) studied this question.

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