October 3, 2025PharmaceuticalsOpen Access

Mechanotransduction-Epigenetic Coupling in Pulmonary Regeneration: Multifunctional Bioscaffolds as Emerging Tools

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Substantial reductions in collagen deposition highlight the potential of bioscaffolds in treating pulmonary fibrosis.
Murine model evidence reveals significant increases in alveolar epithelial cell markers after scaffold interventions.
Scaffold properties, such as stiffness gradients, influence cell fate through mechanotransduction pathways and epigenetic changes.
Challenges remain in erasing pathological mechanical memory to fully harness bioscaffold therapeutic capabilities.

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This review demonstrates multifunctional bioscaffolds improving pulmonary fibrosis via mechanotransduction and epigenetic modulation.

Wang et al. (2025) studied this question.

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