The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications

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Pulmonary fibrosis is a progressive and fatal disease marked by excessive accumulation of extracellular matrix.
Recent advances highlight that epigenetic changes, like DNA and RNA methylation, influence pulmonary fibrosis development.
Cellular processes such as fibroblast-to-myofibroblast transition and epithelial-to-mesenchymal transition are critical in PF progression.
Insights into epigenetics pave the way for new therapeutic approaches to manage or potentially treat pulmonary fibrosis.

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This review uncovers epigenetics' role in pulmonary fibrosis and reveals potential therapeutic implications.

Huang et al. (2025) studied this question.

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