September 10, 2025Scientific ReportsOpen Access

Ginkgolide B attenuates hyperlipidemia by restoring sphingolipid homeostasis and activating PPARα and Nrf2 pathways

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Ginkgolide B decreases triglycerides and cholesterol in hyperlipidemic rats, highlighting its potential in lipid metabolism disorders.

Ginkgolide B significantly reduced serum cholesterol, triglycerides, and LDL levels.
Lipidomics analysis showed Ginkgolide B restored sphingolipid metabolism by lowering ceramides.
Activation of PPARα and the Nrf2 pathway mitigated oxidative stress and improved fatty acid oxidation.
In vitro studies confirmed Ginkgolide B reduced lipid accumulation in HepG2 cells, enhancing antioxidant defenses.

Liu et al. (2025) studied this question.

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