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September 10, 2025Acta Biochimica Iranica

The Diverse Roles of Hyaluronidase: Revealing Its Biochemical, Preclinical, and Clinical Applications

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Authors

MSMahdiyeh SafaryMTMobina TajdariAPAmirreza Peyrovinasab

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Overview

This review highlights hyaluronidase's crucial roles in drug delivery and tissue remodeling, indicating various clinical applications.

Key Points

  • Hyaluronidase effectively modulates the extracellular matrix and enhances tissue permeability, benefiting various medical fields.
  • The review details its role in drug delivery, highlighting how it can improve therapeutic effectiveness across multiple domains.
  • Preclinical studies reveal hyaluronidase's importance in cancer research, underscoring its potential in innovative treatment strategies.
  • Despite its advantages, the review emphasizes challenges like immunogenicity and variability in enzyme sources that still need further exploration.

Cite This Study

Safary et al. (2025) studied this question.

synapsesocial.com/papers/68c23d81b210217d6478d6c4https://doi.org/10.18502/abi.v3i2.19483
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hyaluronidases as Targets for the Treatment of Neurological Diseases2025 · 1 citations
  2. 2Effectiveness of Hyaluronidase on Hyaluronic Acid Degradation: An Experimental Study2025
  3. 3Characterization of a Hyaluronidase from Paenibacillus residui BSSK58 and Evaluation of Its Industrial Applicability2025
  4. 4Engineering Strategies for Hyaluronan Synthesis: A Review of Enzyme Modifications, Strain Selection, and Molecular Weight Control2025
  5. 5Applications of Hyaluronic Acid in Pharmaceuticals, Healthcare and Cosmetics and Its Biosynthesis2026