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September 25, 2025Proteoglycan ResearchOpen Access

Hyaluronidases as Targets for the Treatment of Neurological Diseases

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Authors

LSLarry S. ShermanBSBarbara A. SorgSMSteven G. Matsumoto

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Overview

Review reveals hyaluronidases impact recovery in neurological diseases, indicating their role as therapeutic targets.

Key Points

  • Hyaluronidase activity is elevated in the central nervous system following injuries, impacting recovery.
  • Increased hyaluronan synthesis in conditions like neuroinflammation suggests a link with hyaluronidase expression.
  • Therapeutic agents targeting hyaluronidases may improve outcomes in neuroinflammatory diseases and dementia.
  • Distinct biological activities of HA digestion products influence recovery from CNS damage.

Cite This Study

Sherman et al. (2025) studied this question.

synapsesocial.com/papers/68d5e1ffbd7882ccb9b866d2https://doi.org/10.1002/pgr2.70036
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Also Consider

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