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September 10, 2025Deleted JournalOpen Access

Neuroprotection by Resveratrol in Chronic Cerebral Hypoperfusion: A Study on Synaptogenesis Enhancement and Apoptosis Inhibition

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Authors

AKAbdollah KasaeiMFMohsen ForouzanfarMJMojtaba Jafarinia

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Overview

This study examines how resveratrol enhances synaptogenesis and inhibits apoptosis in rats with chronic cerebral hypoperfusion, suggesting therapeutic benefits for vascular dementia.

Key Points

  • Resveratrol at 5 mg/kg significantly improved spatial memory and reduced neuronal apoptosis.
  • Treatment with resveratrol resulted in increased anti-apoptotic Bcl-2 expression and decreased Bax expression.
  • The study utilized a rat model of chronic cerebral hypoperfusion to assess cognitive function via Morris water maze and other tests.
  • These results support the potential of resveratrol as a therapeutic agent for vascular cognitive impairment.

Cite This Study

Kasaei et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478ce53https://doi.org/10.5812/ijpr-162425
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