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September 11, 2025Brain and BehaviorOpen Access

Long‐Term Treadmill Exercise and Voluntary Running Pre‐Training Attenuates Vascular Dementia‐Related Pathology by Regulating Hippocampal Structural Synaptic Plasticity in a Rat Model

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Authors

YLYujiao LiYLYuxuan LiLZLinlin Zhang

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Overview

This analysis shows that exercise pretreatment improves cognition in vascular dementia rats, suggesting exercise may enhance synaptic plasticity.

Key Points

  • Long-term exercise significantly reduces cognitive impairment in vascular dementia rat models, supporting its therapeutic effects.
  • Decreased neurotransmitter levels in vascular dementia were reversed by exercise, highlighting neuroprotective impacts.
  • Immunofluorescent staining indicated reduced neuronal apoptosis in rats following treadmill or voluntary running exercises.
  • Examining synaptic structures revealed that exercise enhances synaptic plasticity in the hippocampus, improving overall brain health.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d418d4713b0b5dfea643cahttps://doi.org/10.1002/brb3.70833
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Also Consider

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  1. 1Effect of Post‑Induction Treadmill Exercise on Hippocampal Agrin and Laminin in a Rat Model of Alzheimer’s Disease: Relevance to Hippocampal Sclerosis2025
  2. 2Cognitive stimulation exerts long-lasting protective effects on the hippocampal vasculature and memory function in a rat model of vascular cognitive impairment2025
  3. 3Combined Exercise and Ursolic Acid Improve Hippocampal Neuronal Markers and Exploratory‐Locomotor Behavior in Aged Diabetic Rats2025
  4. 4Effects of ageing and exercise training on cerebrovascular vasomotor reactivity, depressive behaviour and the hippocampal transcriptome2025
  5. 5Ischemic stroke rehabilitation through endurance training of varying intensity and duration in male Sprague-Dawley rats.2025