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September 12, 2025Open Access

Protective Effects of Curcumin and Resveratrol on Neurodegeneration and Cognitive Dysfunction in a Streptozotocin-induced Alzheimer Rat Model

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DSDerya Öztürk SöylemezEUErdoğan UnurDSDilek Sağır

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Overview

This study reveals that curcumin and resveratrol improve cognitive dysfunction in a rat model of Alzheimer's, suggesting neuroprotective properties.

Key Points

  • Curcumin and resveratrol significantly improved cognitive dysfunction in the Alzheimer rat model.
  • Behavioral tests showed improvement in neurobehavioral outcomes along with reduced neuronal apoptosis.
  • Histological analyses confirm reduction in oxidative stress and neuroinflammation induced by streptozotocin.
  • Combination therapy showed no synergistic effect, indicating that each compound works best alone.

Cite This Study

Söylemez et al. (2025) studied this question.

synapsesocial.com/papers/68d41da8713b0b5dfea6708ehttps://doi.org/10.21203/rs.3.rs-6363905/v2
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